Search for dissertations about: "chlomethiazole"

Found 2 swedish dissertations containing the word chlomethiazole.

2. 1. Molecular basis for the anti-inflammatory properties of chlomethiazole

   Author : Anastasia Simi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Stroke; neuroprotection; p38 MAP kinase; chlomethiazole; interleukin-1; c-fos; inflammation; glia; lipopolysaccharide; molecular mechanisms; ischaemia;

   Abstract : Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage by inhibiting the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. READ MORE

4. 2. Genetic polymorphism and regulation of cytochrome P450 2E1

   Author : Yin Hu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cytochrome P450 2E1 (CYP2E1) participates in the metabolism of several xenobiotics. A physiological role of CYP2E1 is its ability to convert acetone into gluconeogenetic precursors. Due to a pronounced oxidase activity CYP2E1 can generate substantial amount of oxygen free radicals and may contribute to oxidative stress. READ MORE