Search for dissertations about: "cholesterol detection"

Showing result 1 - 5 of 21 swedish dissertations containing the words cholesterol detection.

  2. 1. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

    Author : Louise M Carlred; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

    Abstract : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. READ MORE

  4. 2. Lipid-Based Surface Modifications: towards the Development of Membrane-Protein Arrays

    Author : Indriati Pfeiffer; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; DNA-array; cholesterol-DNA; EIS; membrane proteins; lipid vesicles; QCM-D; supported lipid bilayer;

    Abstract : Mimics of the natural cell membrane, such as lipid vesicles and supported lipid membranes, have gained significant attention in recent years. This is primarily due to their ability to provide scientists with a model system allowing a large arsenal of scientific tools to be used in studies of biological reactions that are naturally controlled by the cell membrane and its components. READ MORE

  5. 3. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Author : Hampus Hedlund; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Abstract : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. READ MORE

  6. 4. Translational studies on Alzheimer’s disease : a focus on cholesterol metabolism, thioredoxin-80 and microglia function

    Author : Julen Goicolea; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Disturbances in cholesterol metabolism and inflammatory processes may have a negative impact on brain health. These two aspects are considered to be signs of early changes in Alzheimer’s Disease (AD). However, clear molecular links between them as well as mechanisms for their early detection are missing in the context of neurodegeneration and AD. READ MORE

  7. 5. Novel reagentless electrodes for biosensing

    Author : Alina Sekretaryova; Mats Eriksson; Mikhail Vagin; Anthony Turner; Sergey Shleev; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Analytical chemical information is needed in all areas of human activity including health care, pharmacology, food control and environmental chemistry. Today one of the main challenges in analytical chemistry is the development of methods to perform accurate and sensitive rapid analysis and monitoring of analytes in ‘real’ samples. READ MORE