Search for dissertations about: "cholesterol insulin secretion"

Showing result 1 - 5 of 33 swedish dissertations containing the words cholesterol insulin secretion.

  2. 1. Membrane rafts and its GPI anchored complement inhibitors regulate insulin secretion

    Author : Vini Nagaraj; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Membrane rafts; basal insulin secretion; regulated insulin secretion; CD59; CD55; SNARE proteins; insulin; pancreatic beta cells.;

    Abstract : Type 2 diabetic patients usually exhibit an abnormal lipid profile. One such lipid that is constantly elevated in T2D is cholesterol. At the cellular level, cholesterol aids in tight packing of sphingolipids in certain regions of the plasma membrane and these specialized regions are termed ‘membrane rafts’, which act as signalling hubs. READ MORE

  4. 2. Phosphoinositides control insulin secretion through multiple routes

    Author : Phuoc My Nguyen; Christina Bark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phosphoinositides; PI 4 P; PI 4; 5 P2; Ca2 ; optogenetics; VDCC; Sac2; OSBP; OSW-1; cholesterol; membrane contact sites;

    Abstract : Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are minor components of all cellular membranes, yet play fundamental roles as regulators of many cellular processes. READ MORE

  5. 3. GH, IGF-1 and insulin in the regulation of lipid and lipoprotein metabolism

    Author : Fredrik Frick; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth-hormone; insulin-like growth factor-I; insulin; lipoprotein lipase; adipose tissue; muscle tissue; VLDL secretion;

    Abstract : It is well known that growth hormone (GH) has profound effects on lipid and lipoprotein metabolism. Insulin-like growth factor-I (IGF-I) is believed to mediate some of the effects of GH via endocrine and paracrine mechanisms. Moreover, both GH and IGF-I are known to influence insulin secretion. READ MORE

  6. 4. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Author : Jenny Vikman; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Abstract : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. READ MORE

  7. 5. Apolipoprotein A-I in glucose metabolism and amyloidosis

    Author : Oktawia Nilsson; Medicinsk proteinvetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Apolipoprotein A-I; beta cell; cardiovascular disease; cholesterol efflux; diabetes; glucose metabolism; glycation; high-density lipoprotein; insulin secretion;

    Abstract : The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. READ MORE