Search for dissertations about: "cholesteryl esters"

Showing result 11 - 13 of 13 swedish dissertations containing the words cholesteryl esters.

2. 11. Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets

   Author : Mirko Enea Minniti; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, massive research efforts are allocated to identify the pathophysiological mechanisms and new therapeutic targets for these morbidities. READ MORE

4. 12. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

   Author : Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

   Abstract : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. READ MORE

5. 13. Establishment of new potential biomarkers for cardiometabolic diseases

   Author : Karin Littmann; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cardiometabolic diseases is a growing health issue worldwide. New knowledge about the pathophysiological processes have been gained and several research discoveries have contributed to better management of the diseases. Even so, the prognosis, diagnosis, and treatment of cardiometabolic diseases needs to be further improved. READ MORE