Search for dissertations about: "chondrocyte"

Showing result 6 - 10 of 48 swedish dissertations containing the word chondrocyte.

  2. 6. Effects of growth factors on chondrocyte proliferation and differentiation

    Author : Caroline Edwall-Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Growth plate cartilage; limb buds; growth factors; proliferation; differentiation; collagens; c-fos; ALP;

    Abstract : Longitudinal bone growth is regulated at the level of growth plate chondrocytes by circulating or locally produced hormones and growth factors. Present investigation focused on the effects of growth hormone (GH) and growth factors on chondrocyte proliferation and differentiation during pre- and postnatal cartilage development. READ MORE

  4. 7. Responses of fibroblasts and chondrosarcoma cells to mechanical and chemical stimuli

    Author : Juha Piltti; Mikko Lammi; Jukka Häyrinen; Frank Beier; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-kinase inhibition; Y-27632; hypoxia; cyclic stretching; human chondrosarcoma 2 8 cells; chondrocyte phenotype; fibroblasts; proteomics; protein pathway analytics; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Osteoarthritis is an inflammation-related disease that progressively destroys joint cartilage. This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints. Therefore, it often restricts daily activities and the ability to work. READ MORE

  5. 8. Chondrocytes Differentiation- Biological and Biomaterial Perspectives

    Author : Hanna Stenhamre; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scaffold.; chondrocyte implantation; cartilage tissue engineering; dedifferentiation; redifferentiation;

    Abstract : Articular cartilage is an avascular tissue and once injured it does not heal spontaneously. A successful tissue engineering approach for cartilage reconstruction is autolougus chondrocyte implantation (ACI). READ MORE

  6. 9. Effects of chemotherapy on bone growth and chondrocyte cell death signaling

    Author : Farasat Zaman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glucocorticoids (GCs) are widely used in both children and adults to treat common inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis and Crohn’s disease. However, a multitude of undesired side effects have been reported in patients being treated with GCs, such as osteoporosis, obesity, metabolic disturbances, myopathy and decreased linear bone growth (in children). READ MORE

  7. 10. The role of the microenvironment in growth plate and articular chondrocyte differentiation

    Author : Zelong Dou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One crucial process during skeletal development is joint formation. It starts with the interzone appearance characterized by high expression of Gdf5, Gli3, Wnt4 and Wnt9a, low expression of Col2a1 of the local compact elongated cells which subsequently give rise to most joint elements including articular cartilage as the ongoing joint cavitation. READ MORE