Search for dissertations about: "chromatin remodeling"

Showing result 6 - 10 of 53 swedish dissertations containing the words chromatin remodeling.

  2. 6. Allosteric control of ALC1-catalyzed nucleosome remodeling

    Author : Laura C. Lehmann; Sebastian Deindl; Stefan D. Knight; Felix Müller-Planitz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; ATP-dependent chromatin remodeling; nucleosome; allosteric regulation; autoinhibition; macro domain; PARP; ADP-ribosylation; DNA damage; acidic patch; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin. This packaging restricts access to the DNA and therefore represents a barrier for processes such as DNA replication, repair, and gene expression. READ MORE

  4. 7. Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization

    Author : Babett Steglich; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence accessibility of DNA elements. READ MORE

  5. 8. Chromatin remodeling and dna topology in transcription and genome stability

    Author : Jenna Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. DNA packaging into chromatin both solves and creates problems. It allows the centimeters, or even meters, of DNA that constitute a eukaryotic genome to fit inside a micrometer-scale cell nucleus. READ MORE

  6. 9. ATPase dependent and independent roles of Brahma in transcription and pre-mRNA processing

    Author : Simei Yu; Neus Visa; Ann-Kristin Östlund Farrants; Christian Muchardt; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chromatin remodeling; transcription; alternative splicing; 3 -end processing; Molecular Biology; molekylärbiologi;

    Abstract : SWI/SNF is a chromatin-remodeling complex and Brahma (BRM) is the ATPase subunit of SWI/SNF. BRM regulates transcription by remodeling the nucleosomes at promoter regions. BRM is also associated with RNA and affects pre-mRNA processing together with other SWI/SNF subunits. READ MORE

  7. 10. Intrinsic subtypes and prognostic implications in epithelial ovarian cancer

    Author : Jenny-Maria Jönsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; gene expression profiling; Lynch syndrome; targeted deep sequencing; chromatin remodeling; molecular subtypes; endocrine receptors; prognostic factors; tumor heterogeneity;

    Abstract : Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. READ MORE