Search for dissertations about: "chromatin-modifiers"

Showing result 1 - 5 of 7 swedish dissertations containing the word chromatin-modifiers.

  2. 1. Mining DNA elements involved in targeting of chromatin modifiers

    Author : Philge Philip; Per Stenberg; Jan Larsson; Stein Aerts; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleosome; histone; chromatin; chromatin modifiers; targeting; DNA motifs; protein factors; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. READ MORE

  4. 2. The interplay of transcription and chromatin regulation during embryonic development

    Author : George Hunt; Mattias Mannervik; Eileen Furlong; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription; chromatin; chromatin-modifiers; p300 CBP; Polycomb repression; promoter proximal Pol II pausing; molekylär biovetenskap; Molecular Bioscience;

    Abstract : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. READ MORE

  5. 3. Epigenetic Regulation by Noncoding RNA

    Author : Tanmoy Mondal; Chandrasekhar Kanduri; Jérôme Cavaillé; Uppsala universitet; []
    Keywords : Genomic Imprinting; Noncoding RNA; Epigenetics; DNA methylation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. READ MORE

  6. 4. Transcriptional regulation of neural development and degeneration

    Author : Giulia Gaudenzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, transcription factors and chromatin modifiers work together to coordinate gene expression programs that drive the formation of the cerebral cortex. READ MORE

  7. 5. Molecular and epigenetic control of CNS tumour and progenitor cells

    Author : Aileen Gracias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances in treatment, continues to demonstrate a median time of survival of 14.6 months. READ MORE