Search for dissertations about: "chromosomal alterations"
Showing result 11 - 15 of 81 swedish dissertations containing the words chromosomal alterations.
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11. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells
Abstract : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. READ MORE
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12. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
Abstract : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. READ MORE
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13. Rectal Cancer - Tumor Biology and Prognostic Markers
Abstract : Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. READ MORE
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14. Characterisation of molecular alterations in diffuse large b-cell lymphoma with respect to transformation, progression and prognostic markers
Abstract : Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma type, and comprises nearly 500 newly diagnosed cases in Sweden every year. DLBCL is a group of aggressive lymphomas that are extremely heterogeneous and differ in morphology, immunophenotype, molecular and clinical features as well as in response to therapy. READ MORE
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15. Fluorescence in situ hybridization for the detection of genetic alterations in prostate and bladder malignancies : significance as a genetic marker to predict the patient prognosis
Abstract : Prostate cancer and bladder cancer are common urological malignancies in man, while a lack of basic information underlying the oncogenesis and the tumor progression makes it difficult to form therapeutic strategies against these malignancies. Recent advances of molecular biology revealed that genetic alteration play a crucial role in the oncogenesis and progression of these tumors. READ MORE