Search for dissertations about: "chromosomal alterations"

Showing result 16 - 20 of 81 swedish dissertations containing the words chromosomal alterations.

  2. 16. Approaches for the localization and identification of human cancer genes

    Author : Wong-Onn Lui; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CGH; FISH; SKY; karyotyping; SNP array; expression array; VHL-associated pheochromocytomas; hemangioblastomas; familial renal cell carcinoma; constitutional translocation; sporadic follicular thyroid tumors; chromosomal alterations; fusion oncogene; FTCF-PPAR gamma l; PAX8-PPAR gamma l.;

    Abstract : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. READ MORE

  4. 17. Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation

    Author : Mattias Berglund; Gunilla Enblad; Svetlana Lagercrantz; Christer Sundström; Catharina Larsson; Ingemar Ernberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Diffuse large B-cell lymphoma; Hodgkin lymphoma; follicular lymphoma; transformation; comparative genomic hybridization; prognosis; Onkologi; Oncology; Onkologi;

    Abstract : Lymphomas are a heterogeneous group of neoplasias originating from B- or T-lymphocytes. In this thesis, we determined the genetic and immunophenotypic characterization of DLBCL and their prognostic impact. READ MORE

  5. 18. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Author : Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Abstract : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. READ MORE

  6. 19. Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species

    Author : Nagwa Mustafa El Amin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of antibacterials with broad spectrum of activity, carbapenems and fluoroquinolones. READ MORE

  7. 20. Identification of protein signatures of genomic stability/instability in epithelial cancers

    Author : Timo Gemoll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aneuploidy is a consistent genetic alteration of the cancer genome. At early steps in the sequence of malignant transformation during human tumorigenesis, chromosomal aneuploidies can be the first detectable genetic aberrations found. READ MORE