Search for dissertations about: "chromosomal alterations"
Showing result 21 - 25 of 81 swedish dissertations containing the words chromosomal alterations.
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21. Molecular Interrogation and Functional Studies of Acute Leukemia
Abstract : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. READ MORE
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22. Genetic characterization of hematological malignancies with focus on mantle cell lymphoma
Abstract : Lymphoid cancer affects about 2000 individuals in Sweden every year. Lymphoma is divided into numerous subclasses based on histopathological and phenotypic characterization, however, for some lymphoma entities, the classification criteria are insufficient and clinical diversity is seen in cases of the same diagnosis. READ MORE
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23. Horizontal gene transfer by uptake of apoptotic bodies
Abstract : In adults as well as during embryogenesis, apoptosis plays a key role in the elimination of cells in multicellular organisms. Apoptosis is important for the maintenance of tissue homeostasis. It is also of importance in tumor development, where tumor cells die by apoptosis due to low levels of oxygen and nutrients. READ MORE
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24. Application of Genomic and Expression Arrays for Identification of new Cancer Genes
Abstract : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. READ MORE
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25. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia
Abstract : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. READ MORE