Search for dissertations about: "chromosomal regions"

Showing result 1 - 5 of 129 swedish dissertations containing the words chromosomal regions.

  2. 1. Genetic Alterations in Lymphoma : with Focus on the Ikaros, NOTCH1 and BCL11B Genes

    Author : Anneli Karlsson; Peter Söderkvist; Shi-Mei Zhuang; Jan-Ingvar Jönsson; Dan Grandér; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell proliferation; Lymphoma; Znfn1a1; Notch1; Bcl11b; chromosomal regions; Ikaros; B-cell lymphomas; Oncology; Onkologi;

    Abstract : Cell proliferation is a process that is strictly regulated by a large number of proteins. An alteration in one of the encoding genes inserts an error into the regulative protein, which may result in uncontrolled cell growth and eventually tumor formation. READ MORE

  4. 2. Structural chromosomal aberrations and neuropsychiatric disorders

    Author : Tonnie Johannesson; Göteborgs universitet; []
    Keywords : Autism spectrum disorders; chromosomes; FISH; balanced; translocations;

    Abstract : Infantile autism (IA) is a severe neurodevelopment disorder with a complex genetic predisposition. The underlying causes of autism are still not understood. READ MORE

  5. 3. Candidate genes and chromosomal loci in multiple sclerosis

    Author : Chun Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with a putatively autoimmune etiology. The pathophysiological basis of MS is incompletely known, although both genetic and environmental factors are presumed to be of importance. READ MORE

  6. 4. Molecular genetics of kidney cancer : chromosomal regions of importance in the development of renal cell carcinoma

    Author : Rikard Erlandsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Carcinoma; renal cell Chromosomes; human; pair 3 Chromosome deletion Genes; suppressor; tumor Sequence analysis; DNA. Renal cell carcinoma RCC is a malignancy of the human kidney; occurring most commonlyduring the seventh and eighth decades of;

    Abstract : Renal cell carcinoma (RCC) is a malignancy of the human kidney, occurring most commonly during the seventh and eighth decades of life. The incidence is high in the Nordic countries and the five year survival is 40-50%. Smoking is a risk factor inferring a minor increase in risk. The best established risk factor is obesity. READ MORE

  7. 5. Involvement of evolutionarily plastic regions in cancer associated CHR3 aberrations

    Author : Eva Darai-Ramqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A functional test to identify tumor antagonizing regions on chromosome 3 (chr3), called the Elimination Test, was developed in our group. It is based on microcell mediated transfer of human chr3 into mouse or human tumor cells and analysis of the monochromosomal hybrids after their growth in vivo. READ MORE