Search for dissertations about: "chronic lymphocytic leukemia"

Showing result 21 - 25 of 85 swedish dissertations containing the words chronic lymphocytic leukemia.

2. 21. Targeted therapy and outcome in chronic lymphocytic leukemia

   Author : Sandra Eketorp Sylvan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Despite major advances, chronic lymphocytic leukemia (CLL) is still considered incurable. Fludarabine refractory patients and those with TP53disruptions have a particularly poor prognosis. Alemtuzumab is an established treatment option for these patients. However, its use is complicated by immunosuppressive side effects. READ MORE

4. 22. Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia

   Author : Anna Olsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : B-CLL; apoptosis; TRAIL; FLIP; Bmf; Bfl-1;

   Abstract : B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, disease progression and resistance to therapy in BCLL. READ MORE

5. 23. Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma

   Author : Ayla De Paepe; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : With next generation sequencing taking center stage in genetic and epigenetic research, its applications and challenges are many. This work revolves around the application of bioinformatics in different contexts: basic research in the understanding of diseases (biology), the effect of treatment on the target cells (clinics) and the assessment of a new wet-lab method (lab). READ MORE

6. 24. Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia

   Author : Parviz Kokhaei; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Immunotherapy; dendritic cells. chronic lymphocytic leukemia; tumor vaccine; T lymphocyte;

   Abstract : A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for loading antigen on dendritic cells (DC) with the aim of delineating the most effective antigen presentation platform for stimulating anti-leukemic T cells. READ MORE

7. 25. Regulation of growth, differentiation and survival of B-chronic lymphocytic leukemia cells

   Author : Ola Söderberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; B-CLL; B cells; IL-2; IL-4; IL-10; IL-15; CD40-stimulation; SAC; Thioredoxin; proliferation; differentiation; survival; in vitro; EBV; Patologi; Pathology; Patologi; Pathology; patologi;

   Abstract : Chronic lymphocytic leukemia of B cell type (B-CLL) is the most commonform of leukemia in the Western countries. The signals regulating theexpansion of the B-CLL clone in vivo is yet far from being fully understood. READ MORE