Search for dissertations about: "chronic myeloid leukemia CML"

Showing result 6 - 10 of 32 swedish dissertations containing the words chronic myeloid leukemia CML.

2. 6. Myeloid-Derived Suppressor Cells and Other Immune Escape Mechanisms in Chronic Leukemia

   Author : Lisa Christiansson; Angelica S I Loskog; Ulla Olsson-Strömberg; Andreas Lundqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic myeloid leukemia; myeloid-derived suppressor cells; sCD25; tyrosine kinase inhibitors; multiplex protein quantification; Medical Science; Medicinsk vetenskap;

   Abstract : Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, a minute chromosome that leads to the creation of the fusion gene BCR/ABL and the transcription of the fusion protein BCR/ABL in transformed cells. The constitutively active tyrosine kinase BCR/ABL confers enhanced proliferation and survival on leukemic cells. READ MORE

4. 7. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia

   Author : Aikaterini Barbouti; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fluorescent in situ hybridization; low-copy repeats; isochromosome 17q; MSI2 HOXA9; ETV6 ABL1; BCR ABL1; chronic myeloid leukemia; blast crisis; molecular genetics; Clinical genetics; Klinisk genetik;

   Abstract : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. READ MORE

5. 8. Clinical and Genetic studies in Chronic Myeloid Leukaemia

   Author : Hjalmar Flygt; Ulla Olsson Strömberg; Stina Söderlund; Lucia Cavelier; Jane Apperley; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Chronic Myeloid Leukemia; Medicinsk vetenskap; Medical Science;

   Abstract : This thesis explores strategies to enhance deep molecular response (DMR) rates and treatment-free remission (TFR) eligibility in chronic myeloid leukaemia (CML), investigates factors linked to treatment milestone failures, describes tyrosine kinase inhibitor (TKI) discontinuation outcomes in a population-based cohort, and examines TFR probabilities after a second TKI discontinuation. In paper I we examined data from the Swedish CML registry on 128 CML patients in chronic phase with a reported TKI discontinuation of ≥1 month due to DMR. READ MORE

6. 9. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

   Author : Sofia Jönsson; Göteborgs universitet; []
   Keywords : Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

   Abstract : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. READ MORE

7. 10. Targeting NOX2 in cancer

   Author : Ebru Aydin; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; reactive oxygen species; immunotherapy; nox2; nk cells; melanoma; histamine; metastasis; leukemia; aml; cml; kras; mpd;

   Abstract : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. READ MORE