Search for dissertations about: "chronic myeloid leukemia cml"

Showing result 1 - 5 of 32 swedish dissertations containing the words chronic myeloid leukemia cml.

  2. 1. Chronic myeloid leukemia and cancer

    Author : Niklas Gunnarsson; Anders Själander; Martin Höglund; Bertil Lindahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; Prevalence; Malignancies; Odds ratio; Standardized Incidence Ratio; Outcome; Autoimmune diseases; Survival; Epidemiology; epidemiologi; medicin; Medicine;

    Abstract : Background Chronic myeloid leukemia (CML) is a relatively rare hematological malignancy with a constant incidence of approximately 90 new cases each year in Sweden (0.9 cases/100 000 inhabitants). The etiology is largely unknown but high doses of ionizing radiation are a known but rare risk factor. READ MORE

  4. 2. Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia

    Author : Nils Hansen; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; SOCS2; IL1RAP; BCR ABL1; leukemia models;

    Abstract : Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. READ MORE

  5. 3. Targeting residual malignant cells in myeloid leukemia

    Author : Malin Nilsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia; chronic myeloid leukemia; histamine dihydrochloride; hydroxyurea; leukemic stem cells;

    Abstract : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. READ MORE

  6. 4. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression

    Author : Ulla Olsson-Strömberg; Bengt Simonsson; Elin Lindhagen; Gisela Barbany; Johan Richter; Uppsala universitet; []
    Keywords : Medicine; chronic myeloid leukemia; adult; stem cell transplantation; mobilization of Ph-negative stem cells; in vitro assay; imatinib; gene expression; Medicin;

    Abstract : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. READ MORE

  7. 5. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate

    Author : Yuan Wei; Göteborgs universitet; []
    Keywords : CML; imatinib; BCR-ABL; apoptosis; mutation; T-lymphocyte;

    Abstract : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. READ MORE