Search for dissertations about: "ciprofloxacin resistance"

Showing result 1 - 5 of 50 swedish dissertations containing the words ciprofloxacin resistance.

2. 1. Antibiotic resistance gone wild : A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae

   Author : Clara Atterby; Josef D. Järhult; Nicola Williams; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; E. coli; K. pneumoniae; ESBL; AmpC; Carbapenemase; ciprofloxacin resistance; colistin resistance; rural; wildlife; birds; sub-MIC; MSC; Cambodia; environment; epidemiology; Infektionssjukdomar; Infectious Diseases;

   Abstract : Antibiotics have saved millions of lives since they came into clinical use during the Second World War in the 1940s. Today, our effective use of antibiotics is under great threat due to emerging antibiotic resistance in bacteria. This thesis addresses the problems of antibiotic resistance from a ”One Health” perspective. READ MORE

4. 2. Exploring the Ciprofloxacin Resistome

   Author : Linnéa Garoff; Diarmaid Hughes; Jesús Blázquez; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Experimental evolution; Ciprofloxacin; Escherichia coli; Mikrobiologi; Microbiology;

   Abstract : This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug. READ MORE

5. 3. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

   Author : Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
   Keywords : ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

   Abstract : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. READ MORE

6. 4. Evolution of Antibiotic Resistance

   Author : Franziska Pietsch; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
   Keywords : ciprofloxacin; rifampicin; bacterial fitness; compensation; mutation rate; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE

7. 5. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

   Author : Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
   Keywords : pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. READ MORE