Search for dissertations about: "ciprofloxacin"

Showing result 11 - 15 of 63 swedish dissertations containing the word ciprofloxacin.

  2. 11. Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae

    Author : Emma Lindbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Neisseria gonorrhoeae; ciprofloxacin; DNA-gyrase; topoisomerase IV; major outer membrane protein;

    Abstract : A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA replication. READ MORE

  4. 12. Antibiotic resistance gone wild : A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae

    Author : Clara Atterby; Josef D. Järhult; Nicola Williams; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; E. coli; K. pneumoniae; ESBL; AmpC; Carbapenemase; ciprofloxacin resistance; colistin resistance; rural; wildlife; birds; sub-MIC; MSC; Cambodia; environment; epidemiology; Infektionssjukdomar; Infectious Diseases;

    Abstract : Antibiotics have saved millions of lives since they came into clinical use during the Second World War in the 1940s. Today, our effective use of antibiotics is under great threat due to emerging antibiotic resistance in bacteria. This thesis addresses the problems of antibiotic resistance from a ”One Health” perspective. READ MORE

  5. 13. Optimization of cyclophosphamide therapy based on pharmacogenetics

    Author : Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

    Abstract : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. READ MORE

  6. 14. Determination of Antibiotics in the Swedish Environment with Emphasis on Sewage Treatment Plants

    Author : Richard Lindberg; Barbro Andersson; Mats Tysklind; Magnus Johansson; Alfredo Alder; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotics; environment; sewage treatment plants; antibiotika; miljö; avloppsreningsverk; Environmental chemistry; Miljökemi;

    Abstract : Metoder har utvecklats för att kunna bestämma tolv antibiotikasubstanser, vanliga inom human medicin, i miljöprover. Fokus lades på trimetoprim samt substanser från följande grupper: fluorokinoloner, sulfonamider, penicilliner, cefalosporiner, nitroimidazoler, tetracykliner samt makrolider. READ MORE

  7. 15. Mutations and Mutation Rate in the Development of Fluoroquinolone Resistance

    Author : Patricia Komp Lindgren; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Keywords : Microbiology; Mutation rate; Fluoroquinolone; Resistance; Biological fitness; Urinary tract infection; Escherichia coli; MPC; Mikrobiologi;

    Abstract : The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation. READ MORE