Search for dissertations about: "circular dichroism"

Showing result 21 - 25 of 115 swedish dissertations containing the words circular dichroism.

  2. 21. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins

    Author : Martin Lidman; Gerhard Gröbner; Magnus Wolf-Watz; Philip Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bax; Bc-2; apoptosis; mitochondria; membranes; oxidized lipids; NMR; calorimetry; circular dichroism; biokemi; Biochemistry; fysikalisk kemi; Physical Chemistry;

    Abstract : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. READ MORE

  4. 22. Conformational Studies of Biologically Active Peptides

    Author : Björn Walse; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Abstract : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. READ MORE

  5. 23. Structural characterization of proteins to investigate their roles in diseases: Focus on MID & LTA4H

    Author : Mahmudul Hasan; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Moraxella IgD binding protein; adhesin; leukotriene A4 hydrolase; small angle x-ray scattering; crystallography; circular dichroism;

    Abstract : Protein molecules are responsible for many biological functions in cells. In order to fulfill their various biological roles, these chain-like molecules must fold into precise three-dimensional shapes. The knowledge of accurate molecular structures is a prerequisite for rational drug design and for structure based functional studies. READ MORE

  6. 24. Expanding the alphabet of fluorescent nucleic acid base analogues: Characterization of new members

    Author : Anke Dierckx; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fluorescent adenine analogue; fluorescent DNA base analogue; duplex stability; Fluorescence quantum yield; circular dichroism; B-DNA;

    Abstract : Fluorescence has proven to be a powerful tool for studying structure, dynamics and interactions of biomolecules such as proteins, RNA and DNA. However, since the natural DNA/RNA nucleobases are virtually non-fluorescent, there is a need for developing fluorescent nucleic acid markers. READ MORE

  7. 25. Fluorescent Nucleobase Analogues and their use for Investigating DNA Interactions

    Author : Anke Dierckx; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; FRET; B-DNA; circular dichroism; fluorescent nucleobase analogue; adenine analogue; duplex stability; Fluorescence quantum yield;

    Abstract : Ever since unravelling the structure of DNA, an expanding research field has emerged with ongoing efforts dedicated to increase our understanding of the molecule of life. Since the natural nucleobases are virtually non-emissive, it has been a challenge for decades to ‘light up’ DNA/RNA in order to investigate their properties utilizing fluorescence techniques. READ MORE