Search for dissertations about: "cis-regulatory changes"

Showing result 1 - 5 of 7 swedish dissertations containing the words cis-regulatory changes.

2. 1. Cis-regulatory variation and divergence in Capsella

   Author : Kim A. Steige; Tanja Slotte; Jeff J. Doyle; Uppsala universitet; []
   Keywords : Capsella; Shepherd s Purse; cis-regulatory changes; allele-specific expression; mating system shift; floral evolution; polyploidy; positive selection; purifying selection; transposable elements; small RNA; methylation; transposable element silencing; distribution of fitness effects;

   Abstract : Cis-regulatory changes in e.g. promoters or enhancers that affect the expression of a linked focal gene have long been thought to be important for adaptation. In this thesis, I investigate the selective importance and genomic correlates of cis-regulatory variation and divergence in the genus Capsella, using massively parallel sequencing data. READ MORE

4. 2. Gene regulatory evolution in flycatchers: statistical approaches for the analysis of allele-specific expression

   Author : Mi Wang; Hans Ellegren; Christopher Wheat; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ASE; gene expression evolution; bayesian; RPASE; flycatcher.; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : Understanding the molecular mechanisms underlying evolutionary changes in gene expression is a major research topic in biology. While a powerful approach to study this is the analysis of allele-specific expression (ASE), most of previously published methods can only be applied to lab organisms. READ MORE

5. 3. The HDZip Class I Transcription Factors in Arabidopsis thaliana : Characterisation of HDZip Genes Involved in the Mediation of Environmental Signals

   Author : Eva Henriksson; Peter Engström; Julio Salinas; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant physiology; Växtfysiologi; Plant physiology; Växtfysiologi;

   Abstract : Homeodomain leucine zipper (HDZip) proteins constitute a large family of transcription factors characterised by the presence of a DNA-binding homeodomain and an adjacent leucine zipper motif, which mediates protein-dimer formation. The HDZip genes of Arabidopsis have been divided into four classes, HDZip I-IV. READ MORE

6. 4. From Single Gene to Whole Genome Studies of Human Transcription Regulation

   Author : Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
   Keywords : Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

   Abstract : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. READ MORE

7. 5. Morphogen interpretation in the developing nervous system

   Author : Sanja Kurdija; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Development of the central nervous system relies on the generation of specialized cell types in a tightly controlled spatial and temporal order from neural progenitor cells. Morphogen molecules, secreted by defined sources, spatially organize neural progenitors by inducing discrete expression patterns of cell fate determinant genes in a concentration-dependent manner. READ MORE