Search for dissertations about: "cisplatin treatment"

Showing result 1 - 5 of 87 swedish dissertations containing the words cisplatin treatment.

  2. 1. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

    Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

    Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

  4. 2. Bacterial toxins for cancer treatment

    Author : David Johansson; Parviz Behnam-Motlagh; Kjell Grankvist; Anders Johansson; Roger Henriksson; Bo Baldetorp; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha‐toxin; AC‐toxin; mesothelioma; lung cancer; glioma; breast cancer; caspases; MAP-Kinase; verotoxin‐1; cisplatin; apoptosis; Gb3; drug resistance; Clinical chemistry; Klinisk kemi;

    Abstract : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. READ MORE

  5. 3. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA

    Author : Johan Raber; David van der Spoel; Paolo Carloni; Uppsala universitet; []
    Keywords : Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Abstract : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. READ MORE

  6. 4. Electropermeabilization in Experimental Tumour Treatment: Dosimetry and Tissue Effects

    Author : Per Engström; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; liver; electroporation; ischemia; Electropermeabilization; ECT; Tumor; 111-In-BLMC; 99m-Tc-DTPA; glioma; rat; electric pulses; Impedance spectrometry; treatment; Physics; Fysik;

    Abstract : Short, electric high-voltage pulses can be used to transiently increase the permeability of cell membranes without significant loss of cell viability. During this period of time, extracellular and normally non-permeant, molecules are accessed the cytoplasm and the cell nucleus. READ MORE

  7. 5. Studies of radioactive cisplatin (191Pt) for tumour imaging and therapy

    Author : Johan Areberg; Malmö Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; mice; in vitro; gamma camera; tumour imaging; platinum pharmacokinetics; cisplatin; radioactive; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from 191PtCl4. The 191Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. READ MORE