Search for dissertations about: "class II MHC protein"

Showing result 1 - 5 of 68 swedish dissertations containing the words class II MHC protein.

2. 1. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

   Author : Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

   Abstract : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. READ MORE

4. 2. Avian MHC: variation and selection in the wild

   Author : Helena Westerdahl; MEMEG; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; polymorphism; balancing selection; cDNA; avian malaria; great reed warbler; Djurekologi; bird; Animal ecology; immune defence; MHC class II; Major Histocompatibility Complex; MHC class I;

   Abstract : In vertebrates the Major Histocompatibility Complex (MHC) plays a central role in the specific immune defence against various pathogens. Compared with other coding genes the MHC genes exhibit an extremely high level of polymorphism that is maintained by balancing selection. READ MORE

5. 3. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Author : Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

6. 4. The quality control of MHC class I antigen presentation

   Author : Kajsa M Paulsson; Antigen presentation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperone; assembly; COPI; antigenic peptide; TAP; MHC; tapasin; Immunology; serology; transplantation; Immunologi; serologi;

   Abstract : Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). READ MORE

7. 5. Genetic Variation in Mhc Class II B in Atlantic Salmon: Evolutionary and Ecological Perspectives

   Author : Åsa Langefors; Biodiversitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; recombination; genetic variation; Mhc class II B; Atlantic salmon; evolution; population genetics; Animal ecology; Djurekologi;

   Abstract : The Major Histocompatibility Complex (Mhc) genes are crucial for the recognition of self and non-self peptides by the immune defence system. They are extremely variable in most studied vertebrate species. I have studied the extent and the importance of Mhc variation in Atlantic salmon (Salmo salar), mainly from the Baltic Sea. READ MORE