Search for dissertations about: "classification gene expression profiles"
Showing result 1 - 5 of 24 swedish dissertations containing the words classification gene expression profiles.
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1. Gene Expression Studies of Hematologic Malignacies
Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE
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2. Classification and Computational Methods in Gene Expression Data Analysis
Abstract : The technology of cDNA microarrays has given us the possibility to monitor the state of cells by measuring the activity of thousands of genes simultaneously. This high-throughput techniqe has in cancer research allowed exploratory studies of molecular mechanisms behind for example metastasis and response to therapy. READ MORE
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3. Analyses of genomic and gene expression signatures
Abstract : Biology has entered a challenging, information-intense period where computational experiments are complementing traditional experiments. A plethora of new techniques have allowed biological processes to be investigated on a global scale. READ MORE
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4. Towards a deeper understanding of the human brain
Abstract : Identifying the proteome variation in different parts of the body provides fundamental molecular details, enabling further findings and mapping of tissue specific proteins. By combining quantitative transcriptomics with qualitative antibody based proteomics, the Human Protein Atlas (HPA) project aims to protein profile each human protein-coding gene. READ MORE
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5. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome
Abstract : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. READ MORE