Search for dissertations about: "clones"

Showing result 6 - 10 of 313 swedish dissertations containing the word clones.

  1. 6. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides

    Author : Anders Herrmann; Ulf Göransson; Lars Bohlin; Douglas Kinghorn; Uppsala universitet; []
    Keywords : Pharmacognosy; cyclotide; cytotoxic; anti-tumour; macrocyclic; cyclic cystine knot; Alpine violet; Sweet violet; Viola; Violaceae; chemical modifications; structure-activity studies; mass spectroscopy; cDNA clones; Farmakognosi;

    Abstract : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. READ MORE

  2. 7. Characteristics of EBV-infected B cell lines and B-CLL clones which determine their interaction with lymphocytes

    Author : Javier Federico Avila-Carino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : EBV; Burkitt Iymphoma; CLL; MLC; antiviral response phenotype; cytokines.;

    Abstract : The results concerning T Iymphocyte mediated recognition of Epstein-Barr virus (EBV) carrying Burkitt Iymphoma (BL) cell lines and EBV-infected chronic Iymphocytic leukemia (CLL) B cells contribute to the understanding of the generally harmless host-EBV interaction and may be extrapolated to the fate of normal B cells after EBV infection. The phenotype of EBV negative BL lines resembles resting B cells. READ MORE

  3. 8. Microbial factors and host responses affecting severity of pneumococcal disease and pneumococcal carriage

    Author : Andreas Sandgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Streptococcus pneumoniae; molecular epidemiology; serotype; clonality; clones; antibiotic resistance; virulence; animal model; mice; innate immunity; Toll-like receptors; MyD88; bioluminescence.;

    Abstract : Streptococcus pneumoniae, also known as the pneumococcus, is a human specific bacterium and causes infections like otitis media, sinusitis, pneumonia, sepsis and meningitis. However, these bacteria are also frequent colonizers of the nasopharynx of healthy individuals, especially children. READ MORE

  4. 9. Secondary metabolites associated with plant disease, plant defense and biocontrol : studies of Hymenoscyphus pseudoalbidus, Fraxinus excelsior and Pseudomonas brassicacearum MA250

    Author : Pierre Andersson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []

    Abstract : Secondary metabolites of the fungal ash dieback pathogen Hymenoscyphus pseudoalbidus were investigated. Nine steroidal compounds were isolated from, or detected in, liquid cultures of the fungus. Three were the previously known compounds viridiol, viridin and demethoxyviridiol. READ MORE

  5. 10. Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells

    Author : Stina Feltenmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells. The first part of the thesis (papers I & II) describes the expression of genes involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). READ MORE