Search for dissertations about: "cml"
Showing result 1 - 5 of 52 swedish dissertations containing the word cml.
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1. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
Abstract : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. READ MORE
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2. Targeting NOX2 in cancer
Abstract : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. READ MORE
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3. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma
Abstract : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. READ MORE
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4. Modelling animal populations
Abstract : This thesis consists of four papers, three papers about modelling animal populations and one paper about an area integral estimate for solutions of partial differential equations on non-smooth domains. The papers are: I. Å. Brännström, Single species population models from first principles. READ MORE
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5. Cell Surface Markers as Therapeutic Targets in Myeloid Leukemia
Abstract : .... READ MORE