Search for dissertations about: "co-crystal"

Found 5 swedish dissertations containing the word co-crystal.

  2. 1. Physical properties and crystallization of theophylline co-crystals

    Author : Shuo Zhang; Åke Rasmuson; Per Svensson; Mårten Behm; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Theophylline; oxalic acid; glutaric acid; maleic acid; co-crystal; decomposition temperature; melting temperature; solubility; crystallization; Molecular transport processes in chemical process engineering; Molekylära transportprocesser i kemisk processteknik;

    Abstract : This work focuses on the physical properties and crystallization of theophyline co-crystals. Co-crystals of theophylline with oxalic acid, glutaric acid and maleic acid have been investigated. The DSC curves of these co-crystals show that their first endothermic peaks are all lower than the melting temperature of theophylline. READ MORE

  4. 2. Experimental and Theoretical Studies of Boronic Acids as a Co-Crystal Former

    Author : Mayura Talwelkarshimpi; Andreas J Larsson; Sten Nilsson Lill; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Applied Physics; Tillämpad fysik;

    Abstract : Multi-component molecular crystal materials have become a surging research subject due to their potential for applications in various fields such as pharmaceutics, energetic materials, electronics, etc. Their properties are governed by the arrangement of the constituent molecules and the various non-covalent interactions between them in their solid-state structure. READ MORE

  5. 3. Iron in Haem Biosynthesis. Structural Studies of Ferrochelatase and Frataxin

    Author : Tobias Karlberg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; Molekylär biofysik; Molecular biophysics; Biomedicinska vetenskaper; Biomedical sciences; protein crystallography; ferrochelatase; haem biosynthesis; iron; frataxin;

    Abstract : Ferrochelatase catalyses the synthesis of heme by inserting Fe(II) into protoporphyrin IX. The structure of ferrochelatase from yeast has been determined (2.4 Å). The structure is homodimeric with each of the monomer made up of two Rossmann type domains with an active-site cleft between them. READ MORE

  6. 4. Molecular basis for enhanced T-cell recognition and cross-reactivity

    Author : Eva Allerbring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with peptide/MHC complexes occur throughout the lifespan of T cells, from development to activation, with the origin of the peptide varying between self and foreign. READ MORE

  7. 5. Studies on nuclear receptors involved in drug metabolism

    Author : Göran Bertilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The molecular basis for drug metabolism is starting to emerge as a result of cloning and characterization of a group of nuclear receptors that respond to drugs by transcriptional regulation of key genes encoding enzymes involved in metabolism of commonly used drugs. This thesis describes the identification and functional, as well as the structural, characterization of one of these receptors, the human pregnenolone activated receptor (hPAR, NR1I2) that also has been referred to as the pregnane X receptor (PXR) or the steroid and xenobiotic receptor (SXR) by others. READ MORE