Search for dissertations about: "co-expression network"

Showing result 1 - 5 of 19 swedish dissertations containing the words co-expression network.

2. 1. A genomic approach to smooth muscle differentiation and diversity

   Author : Sven Nelander; Göteborgs universitet; []
   Keywords : Keywords: smooth muscle; phenotype; transcriptional regulation; differentiation; transcriptome; microarray; computational prediction; co-expression network; regulatory sequence analysis; gene module; gene battery;

   Abstract : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. READ MORE

4. 2. Data integration for robust network-based disease gene prediction

   Author : Gabriel Östlund; Erik Sonnhammer; Christos Ouzounis; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Abstract : For many complex diseases the cause/mechanism can be tied not to a single gene and in order to cope with the complexity a systems wide approach is needed. By combining evidence indicative of functional association it is possible to infer networks of protein functional coupling. READ MORE

5. 3. Omics Data Analysis of Complex Diseases and Traits

   Author : Saman Hosseini Ashtiani; Arne Elofsson; Dirk Repsilber; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Omics data; RNA-seq; Microarrays; Metabolomics; Network analysis; Psoriasis; E. coli; Hip osteoporosis; Lung adenocarcinoma; Spearman s correlation coefficient; LC-MS; PCA; DEG; PPI; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Abstract : Following the advent of the high-throughput techniques for producing massive omics data, new possibilities and challenges have also emerged in different fields of biology and medicine. Dealing with such data on different scales with different scopes such as genomics, transcriptomics, proteomics and metabolomics, demands appropriate data collection, preprocessing, statistical analysis, interpretation and visualization. READ MORE

6. 4. Adaptation in two species of Phaseolus with contrasting mating systems

   Author : Le Yu; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : For common bean, the loss of photoperiod sensitivity has been a major pre-requisite for domestication and further adaptation to European climates. Its self-pollinated mating system also makes it a good model for identifying genes that display enhanced levels of differentiation in gene expression, together with its closely related species, open-pollinated runner bean. READ MORE

7. 5. Multimodal and multiscale brain networks : understanding aging, Alzheimer’s disease, and other neurodegenerative disorders

   Author : Anna Canal Garcia; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The human brain can be modeled as a complex network, often referred to as the connectome, where structural and functional connections govern its organization. Several neuroimaging studies have focused on understanding the architecture of healthy brain networks and have shed light on how these networks evolve with age and in the presence of neurodegenerative disorders. READ MORE