Search for dissertations about: "co-receptor"

Showing result 1 - 5 of 53 swedish dissertations containing the word co-receptor.

  2. 1. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

    Author : Ulrika Mårtensson; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

    Abstract : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. READ MORE

  4. 2. HIV-1 patient assessment and treatment : from multitest to co-receptor (CCR5) gene polymorphism : from Rgp160 immunization to highly active antiretroviral treatment (HAART)

    Author : Göran Bratt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During the last 15 years, understanding of the pathogenesis of HIV- 1 infection and AIDS has developed rapidly. From a mysterious plague-like untreatable disease with unknown cause and transmission route to a well characterized, chronic, manageable, if yet not curable, retroviral infection. READ MORE

  5. 3. HIV-1 phenotype and genetic variation in vertical transmission

    Author : Peter Clevestig; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV; co-receptor use; diversity; clade; sequon.;

    Abstract : HIV-1 vertical transmission is increasing worldwide despite that successful strategies are available. Reduction of vertical transmission has been established by antiretroviral prophylaxis and elective Caesarian section, but this has been limited to the developed countries. READ MORE

  6. 4. HIV-2 genetic evolution and viral dynamics

    Author : Eleonor Brandin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-2; antiretroviral treatment; resistance; pathogenesis; co-receptor; neutralization; viral dynamics;

    Abstract : HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have investigated different aspects of HIV-2 in order to understand the pathogenesis of HIV-2 better. READ MORE

  7. 5. Binding Kinetics of Proteins at Immune-Cell Contacts

    Author : Manto Chouliara; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; T cells; Binding Kinetics; Affinity; Lifetime; CD4; CD2; TIRF Microscopy; SLBs;

    Abstract : Protein-protein interactions are crucial in numerous cellular functions and biological processes that take place inside our body. It is therefore not surprising that these interactions also govern the response of our body´s defence mechanism, the so-called immune system, towards an infection. READ MORE