Search for dissertations about: "co-stimulation"

Showing result 1 - 5 of 27 swedish dissertations containing the word co-stimulation.

  2. 1. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses

    Author : Eva Gärdby; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunity; PP; cholera toxin; oral immunization; co-stimulation; Th1 Th2;

    Abstract : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. READ MORE

  4. 2. Smoking and T cell co-stimulation in rheumatoid arthritis

    Author : Caroline Wasén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; CD8 T cell; programmed cell death-1; programmed cell death-1 ligand 1; smoking; microRNA;

    Abstract : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. READ MORE

  5. 3. Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation

    Author : Stefanie Marie Renken; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of patients does not benefit from this treatment. READ MORE

  6. 4. On the role of dendritic cells in HIV-1 infection

    Author : Anna Smed Sörensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dendritic cell; plasmacytoid; myeloid; HIV-1; cytokines; co-stimulation; transmission; antigen presentation; apoptotic cells; MuLV;

    Abstract : Dendritic cells (DCs) are antigen-presenting cells with the capacity to initiate primary T cell responses against pathogens such as HIV-1. In addition, DCs express the receptors required for HIV-1 infection and as DCs are prevalent in the mucosa, they encounter the virus early after sexual transmission. READ MORE

  7. 5. Classical cadherins and the thyroid. Studies on organ development and epithelial differentiation

    Author : Mats Grände; Göteborgs universitet; []
    Keywords : Thyroid; cadherin; TGF-; EGF; MEK; development; EMT;

    Abstract : The cadherins are key regulators of tissue patterning and organ formation. E-cadherin is important for cell-cell adhesion and promotes epithelial morphogenesis and maintenance of the epithelial phenotype. READ MORE