Search for dissertations about: "co-translational folding"
Found 4 swedish dissertations containing the words co-translational folding.
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1. Dynamics of peptide chains during co-translational translocation, membrane integration & domain folding
Abstract : The biosynthesis of proteins occurs at the ribosomes, where amino acids are linked together into linear chains. Nascent protein chains may undergo several different processes during their synthesis. Some proteins begin to fold, while others interact with chaperones, targeting factors or processing enzymes. READ MORE
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2. Production and folding of proteins in the periplasm of Escherichia coli
Abstract : The Gram-negative bacterium E. coli is the most widely used host for the production of recombinant proteins. Disulfide bond containing recombinant proteins are usually produced in the periplasm of E. coli since in this compartment of the cell - in contrast to the cytoplasm - disulfide bond formation is promoted. READ MORE
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3. Membrane and secretory protein production in Escherichia coli
Abstract : Escherichia coli (E. coli) is the most widely used bacterium for the production of recombinant proteins. However, the production of proteins in its cytoplasmic membrane or periplasm is challenging. Therefore, the aim of this doctoral thesis was to develop setups for enhancing the production of membrane and secretory proteins in E. READ MORE
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4. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum
Abstract : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). READ MORE