Search for dissertations about: "coagulation factor VIII"

Showing result 16 - 20 of 23 swedish dissertations containing the words coagulation factor VIII.

  2. 16. Haemophilia A - In pursuit of optimised outcomes via personalised treatment

    Author : Alexandros Arvanitakis; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. READ MORE

  4. 17. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

    Author : Petra Evenäs; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. READ MORE

  5. 18. Fast isolation of proteins from bioreactors using affinity chromatography techniques

    Author : Eva Pålsson; Avdelningen för klinisk genetik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chromatography; protein purification; analyses; dispersion; chromatography matrices; Biochemistry; Biokemi; Metabolism; expanded bed; metabolism; Biotechnology; Bioteknik;

    Abstract : The purification of proteins from raw materials like fermentation broth and other biological sources usually involves several purification steps and is rather time consuming and expensive. This is a major concern in the production of many important protein products e.g. pharmaceuticals such as insulin and blood coagulation factors. READ MORE

  6. 19. Structural studies of the ERGIC-53/MCFD2 glycoprotein transport receptor complex

    Author : Edvard Wigren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The secretory pathway defines and maintains the intracellular architecture of the eukaryotic cell. Proteins targeted to either the plasma membrane, the extracellular medium or to specific organelles within the cell are dependent on the correct transfer along this pathway. READ MORE

  7. 20. Co-morbidity and mortality in Swedish patients with haemophilia - A register study

    Author : Susanna Lövdahl; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haemophilia; registry; HIV; viral hepatitis; malignancy; hypertension; cardiovascular disease;

    Abstract : Haemophilia is an X-linked inherited recessive disorder affecting males. The increased risk of hemorrhage is explained by the deficiency in either coagulation factor VIII (haemophilia A) or IX (haemophilia B). The severity of haemophilia A and B is characterized by the bleeding pattern. READ MORE