Search for dissertations about: "cofilin"

Showing result 1 - 5 of 9 swedish dissertations containing the word cofilin.

  2. 1. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Author : Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

    Abstract : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. READ MORE

  4. 2. Intra- and Extracellular Modulation of Integrin-directed Connective Tissue Cell Contraction

    Author : Tijs van Wieringen; Kristofer Rubin; Anders Arner; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Interstitial fluid pressure; PDGF-BB; bacterial proteins; αVβ3 integrin; cytoskeleton; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : All blood vessels in the microvasculature are embedded in loose connective tissue, which regulates the transport of fluid to and from tissues. The intersti-tial fluid pressure (IFP) is one of the forces that control this transport. READ MORE

  5. 3. Extracellular Matrix and Actin Cytoskeleton - the Control Unit of Interstitial Fluid Volume

    Author : Vahid Reyhani; Kristofer Rubin; Markella Ponticos; Uppsala universitet; []
    Keywords : Collagen; fibrin; integrins; PDGF-BB; gel contraction; fluid homeostasis; interstitial fluid pressure; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The regulation of fluid (water) volume in the body is crucial for tissue homeostasis. The interstitial fluid, which comprises almost 20% of the body fluid, is stored in the loose connective tissue and its volume is actively regulated by components of this tissue. READ MORE

  6. 4. Actin and myosin in transcriptional and post-transcriptional control of gene expression

    Author : Ales Obrdlik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Actin plays a key role in basal gene regulation. In the past decade actin has been found to be a component of chromatin remodeling complexes, ribonucleoprotein particles and to associate with all eukaryotic RNA polymerases. READ MORE

  7. 5. Restricted antigen recognition in B cell chronic lymphocytic leukemia

    Author : Anna Lanemo Myhrinder; Anders Rosén; Linköpings universitet; []
    Keywords : Chronic lymphocytic leukemia; auto antigens; CLL cell lines; MEDICINE; MEDICIN;

    Abstract : Chronic lymphocytic leukemia (CLL) cells are considered to be derived from antigen-exposed B cells. To further explore the antigen-driven selection behind the leukemogenesis of CLL, we performed immunoglobulin (Ig) specificity screening of 7 CLL cell lines and 23 primary CLL clones from patient peripheral blood. READ MORE