Search for dissertations about: "colistin resistance"

Showing result 1 - 5 of 11 swedish dissertations containing the words colistin resistance.

  1. 1. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ami Fazlin Syed Mohamed; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. READ MORE

  2. 2. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Kristoffersson; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. READ MORE

  3. 3. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matti Karvanen; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colistin; CMS; Pharmacology; Pharmacokinetics; PKPD; Antibiotics; Combination therapy; Pharmacometrics; Dosing regimens; Antibiotic resistance; Infectious Diseases; Infektionssjukdomar;

    Abstract : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. READ MORE

  4. 4. Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae Antibiotic consumption, Detection and Resistance Epidemiology

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Åse Östholm Balkhed; Linköpings universitet.; Linköpings universitet.; Östergötlands Läns Landsting.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae; Antibiotic consumption; Detection Methods; Multiplex PCR; Resistance Epidemiology; Multi-resistance; E. coli; ESBL; fecal carriage; faecal carriage; travel;

    Abstract : ESBL-producing Enterobacteriaceae are emerging worldwide and they are frequently multi-drug resistant, thus limiting treatment options for infections caused by these pathogens.The overall aim of the thesis was to investigate ESBL-producing Enterobacteriaceae in a Swedish county. READ MORE

  5. 5. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Salim Bouchene; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE