Search for dissertations about: "collagen synthesis"

Showing result 11 - 15 of 62 swedish dissertations containing the words collagen synthesis.

  2. 11. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

    Author : Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
    Keywords : Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

    Abstract : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. READ MORE

  4. 12. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

    Author : Karina Åhlén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. READ MORE

  5. 13. Female stress incontinence and uterovaginal prolapse : collagen turnover and hormone sensitivity in urogenital tissue

    Author : Lena Edwall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Stress incontinence; urogenital tissue; collagen turnover markers; estradiol- 17beta; estrone; testosterone; uterovaginal prolapse; menopause;

    Abstract : Background: Prevalence of both stress urinary incontinence (SUI) and uterovaginal prolapse (UP) is high and rising with age. Risk factors include multiparity, obesity, chronic obstructive lung disease and previous gynecological surgery. The underlying pathology is still unknown but may include defective connective tissue. READ MORE

  6. 14. Mercury-induced autoimmunity : Genetics and immunoregulation

    Author : Monika Hansson; Manuchehr Abedi-Valugerdi; Marita Troye-Blomberg; Lucette Pelletier; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mercury; autoimmunity; collagen-induced arthritis; Th1 Th2; silver; tight-skin 1 mice; Immunology; Immunologi;

    Abstract : The existence of immune self-tolerance allows the immune system to mount responses against infectious agents, but not against self-molecular constitutes. Although self-tolerance is a robust phenomenon, in some individuals as well as in experimental models, the self-tolerance breaks down and as a result, a self-destructive autoimmune disease emerges. READ MORE

  7. 15. Stromal components and micro-RNAs as biomarkers in pancreatic cancer

    Author : Oskar Franklin; Malin Sund; Daniel Öhlund; Ola Billing; Marco Del Chiaro; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; stroma; basement membrane; tumour markers; type IV collagen; endostatin; osteopontin; tenascin c; hyaluronan; CD44; micro-RNA; kirurgi; Surgery;

    Abstract : Background Pancreatic ductal adenocarcinoma (PDAC) patients have the poorest 5-year survival rates of all cancer forms. It is difficult to diagnose at early disease stages, tumour relapse after surgery is common, and current chemotherapies are ineffective. READ MORE