Search for dissertations about: "colorectal cancer rats"

Showing result 1 - 5 of 9 swedish dissertations containing the words colorectal cancer rats.

  2. 1. On the Use of 76Br-labelled Monoclonal Antibodies for PET : Preclinical Evaluation of Halogenated Antibodies for Diagnosis and Treatment of Cancer

    Author : Johanna Höglund; Katrine Riklund-Åhlström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; bromine-76; positron emission tomography; monoclonal antibodies; cancer; direct and indirect radiohalogenation; Onkologi; Oncology; Onkologi; radiologi; Radiology;

    Abstract : Radioactive substances are used in vivo to localize and characterize malignant tumours, generally by scintigraphic methods. In this context positron emission tomography (PET) in combination with radiolabelled monoclonal antibodies (mAbs) may provide a sensitive and specific method for detection of cancer. READ MORE

  4. 2. Alkaline Sphingomyelinase; A Potential Inhibitor in Colorectal Carcinogenesis

    Author : Erik Hertervig; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; oncology; Cytology; Gastroenterologi; Gastro-enterology; HT-29; MIN mouse; FAP; colorectal cancer; human; alkaline sphingomyelinase;

    Abstract : Sphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. READ MORE

  5. 3. Hepatic and Peritoneal Colorectal Metastases : Aspects of Prognosis and Treatment

    Author : Haile Mahteme; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Colorectal cancer; lever metastas; peritoneal metastas; intraperitoneal; tumör reduktion; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Although two-thirds of colorectal cancer patients are cured by surgery, approximately 50% of the patients with this disease develop locally recurrent or distant metastases during the course of their illness. The aim of this study was to identify metastatic sites associated with poor prognosis in rectal cancer and then to investigate methods that can prevent the development and growth of metastases and optimise uptake of drugs at these sites in animal models. READ MORE

  6. 4. Malignant transformation of the colorectal mucosa in inflammatory bowel disease

    Author : Urban Sjöqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Inflammatory bowel disease; ulcerative colitis; colorectal carcinoma; DNA-FCM; aneuploidy; dysplasia; Crohn s disease.;

    Abstract : Ulcerative colitis (UC) and Crohn's disease (CD) are disorders of unknown etiology, often referred to as inflammatory bowel diseases (IBD). The increased risk of colorectal cancer (CRC) in patients with longstanding, extensive colonic IBD is an important clinical problem. READ MORE

  7. 5. Jejunoileal bypass for morbid obesity : studies of the long-term effects

    Author : Anders Sylvan; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Jejunoileal bypass; Obesity; Surgery; Liver biopsy; Fibrinolytic system; Colonoscopy; Flow cytometry; Cancer risk;

    Abstract : This study was aimed at investigating adverse and beneficial long-term effects of jejunoileal bypass (JIB) sugery in obese patients. The JIB was the first widly used surgical procedure for treatment of morbid obesity. The weight loss was remarkable, but the procedure was declared not appropiate for obesity surgery in the late 1970's. READ MORE