Search for dissertations about: "colorectal cancer"
Showing result 16 - 20 of 373 swedish dissertations containing the words colorectal cancer.
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16. From Tissue to Mutations : Genetic Profiling of Colorectal Cancer
Abstract : Comprehensive characterisation of the mutational landscapes of solid tumours is a multistep process involving the collection of suitable samples, the extraction of nucleic acids and the preparation of these materials for mutational analyses. In this thesis, I aimed to develop a streamlined process for the analysis of colorectal cancer (CRC) patient samples in order to identify novel mutations that hallmark the development of advanced disease. READ MORE
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17. Prostanoids and colorectal cancer
Abstract : Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. READ MORE
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18. Someone has to tell them : exploring hereditary cancer risk disclosure in Sweden
Abstract : Summary in EnglishBackground: An awareness of hereditary susceptibility for breast, ovarian and colorectal cancer in high-risk families enables targeted cancer prevention. A discovered hereditary risk in one family member (proband) may thus be important for several members of that family. READ MORE
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19. Antibiotics use in relation to colorectal cancer risk, survival and postoperative complications
Abstract : Background: Growing evidence suggests that antibiotic-induced dysbiosis of gut microbiota potentially contributes to colorectal cancer development and oncological outcomes. However, the role of antibiotics in colorectal cancer incidence, survival and postoperative outcomes at a population level remains incompletely understood. READ MORE
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20. Targeting allelic loss in colorectal cancer
Abstract : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. READ MORE