Search for dissertations about: "column switching"

Showing result 1 - 5 of 10 swedish dissertations containing the words column switching.

  1. 1. Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds

    Author : Björn Arvidsson; Jonas Bergquist; Magnus Wetterhall; Gérard Hopfgartner; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Analytical chemistry; Method development; Enhanced microdialysis; Column switching; Liquid chromatography; Capillary electrophoresis; Electrospray ionization; Mass spectrometry; Triple quadrupole; Time-of-flight; Quantitation; Validation; Analytisk kemi;

    Abstract : Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the ruggedness of the method acquiring the results. In addition to the complexity of the sample matrix, the bioactive compounds targeted for analysis usually have low levels of natural abundance, further increasing the demand on the analytical method sensitivity. READ MORE

  2. 2. Organic acids and siderophores in forest soil solution

    Author : Sara J M Holmström; Mittuniversitetet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; acidification; aluminium; ash treatment; canopy tree; column switching; coniferous; DOC; HPLC-MC; hydroxamate; liming; low molecular weight; organic acids; podzol; porous graphitic carbon; siderophore; soil solution; Chemistry; Kemi;

    Abstract : .... READ MORE

  3. 3. Direct injection of plasma samples into restricted-access media precolumns for drug analysis in column-switching systems

    Author : Zuoxiang Yu; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : This thesis focuses on the theoretical and practical aspects of using column-switching systems for direct injection of plasma samples to assay drugs at ng/ml levels. The systems utilized a restricted-access media (RAM) precolumn for the sample clean-up and trace enrichment. READ MORE

  4. 4. Development of techniques and methods for drug analysis by packed capillary liquid chromatography with octadecylbonded silica and porous graphitic carbon columns

    Author : Pernilla Koivisto; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Kemi; Chemistry; Kemi; Analytical Chemistry; analytisk kemi;

    Abstract : Packed capillary liquid chromatography in combination with ultraviolet and mass spectrometric (MS) detection was explored as an analytical tool for drug analysis. The focus was put on column and sample preparation techniques as well as on fundamental aspects and development of chromatographic separations. READ MORE

  5. 5. Fundamental and Regulatory Aspects of UHPLC in Pharmaceutical Analysis

    Author : Dennis Åsberg; Torgny Fornstedt; Jörgen Samuelsson; Gert Desmet; Karlstads universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Liquid chromatography; UHPLC; Pharmaceutical analysis; Adsorption isotherm; Design of experiments; Quality control; Kemi; Chemistry;

    Abstract : Ultra-high performance liquid chromatography (UHPLC) provides a considerable increase in throughput compared to HPLC and a reduced solvent consumption. The implementation of UHPLC in pharmaceutical analysis, e.g. READ MORE