Search for dissertations about: "combination"

Showing result 1 - 5 of 5549 swedish dissertations containing the word combination.

  1. 1. Data-driven modeling of combination therapy in oncology

    University dissertation from Gothenburg : Chalmers University of Technology

    Author : Tim Cardilin; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling;

    Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

  2. 2. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ami Fazlin Syed Mohamed; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. READ MORE

  3. 3. Modeling of combination therapy to support drug discovery in oncology

    University dissertation from Gothenburg : Chalmers tekniska högskola

    Author : Tim Cardilin; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pharmacokinetics Pharmacodynamics; Oncology; Combination Therapy; Model-Based Drug Development; Nonlinear Mixed-Effects Models;

    Abstract : Mathematical models based on ordinary differential equations, with impulses, are used to describe tumor growth after different treatment combinations, including chemicals as well as radiation. The models are calibrated, using a nonlinear mixed-effects framework, based on time series data of tumor volume from animal experiments. READ MORE

  4. 4. Sensory evaluation and consumer preference of wine and food combinations : influences of tasting techniques

    University dissertation from Örebro : Örebro universitetsbibliotek

    Author : Ingemar Tobias Nygren; Örebro universitet.; [2004]
    Keywords : Descriptive sensory analysis; tasting technique; sequential tasting; mixed tasting; wine; combination; Hollandaise sauce; blue mold cheese; consumers; preference; måltidskunskap; SOCIAL SCIENCES Other social sciences Culinary Arts and Meal Science; SAMHÄLLSVETENSKAP Övrig samhällsvetenskap Måltidskunskap; Måltidskunskap; Culinary Arts and Meal Science;

    Abstract : The entire project consists of five studies. Descriptive sensory analyses were performed on combinations of five dry white wines and either Hollandaise sauce with two levels of fat or two blue mould cheeses. Assessments were carried out by a student panel and by a selected and trained panel. READ MORE

  5. 5. Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts

    University dissertation from Lung Biology

    Author : Lizbet Todorova; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Proteoglycans; Lung fibroblasts; Collagen; Airway remodeling; TGFβ; Glucocorticoids; Combination therapy.; β2-agonist; MMPs;

    Abstract : Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. READ MORE