Search for dissertations about: "combinatorial library"

Showing result 1 - 5 of 50 swedish dissertations containing the words combinatorial library.

  1. 1. Combinatorial Methodology. Screening for affinity specific ligands to biological and artificial receptors

    University dissertation from Pure and Applied Biochemistry, Lund University

    Author : Margareta Krook; [1998]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide library; combinatorial; screening; phage display; affinity; DNA-interaction; chymotrypsin; peptide inhibitor; antibody; IgG; Fc; molecular imprinting; steroid; receptor; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik;

    Abstract : Combinatorial screening methodology has been employed to select new affinity specific ligands to bilogical and artificial receptors. The screening methodology, in particular screening of combinatorial phage display peptide libraries against target molecules differing in function and shape, is focused upon. READ MORE

  2. 2. Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification

    University dissertation from Stockholm : Bioteknologi

    Author : Nina Bandmann; KTH.; [2007]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aqueous two-phase system; combinatorial library; expression vector; flow cytometry; fusion tag; partitioning; peptide library; phage display; recombinant proteins; ribosomal binding site; translation initiation; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Abstract : The bacterium Escherichia coli (E. coli) is in many situations an ideal host for production of recombinant proteins, since it generally provides a rapid and economical means to achieve sufficiently high product quantities. READ MORE

  3. 3. On bacterial formats in protein library technology

    University dissertation from Stockholm : KTH

    Author : Per-Åke Löfdahl; KTH.; [2009]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; β-lactamase; combinatorial library; green fluorescent protein GFP ; protein engineering; protein fragment complementation assay PCA ; selection; TEVprotease; TNF-α; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik; TECHNOLOGY Bioengineering Enzyme engineering; TEKNIKVETENSKAP Bioteknik Enzymteknik;

    Abstract : Millions of years of evolution have resulted in an immense number of different proteins, which participate in virtually every process within cells and thus are of utmost importance for allknown forms of life. In addition, there are several examples of natural proteins which have found use in applications outside their natural environment, such as the use of enzymes infood industry and washing powders or the use of antibodies in diagnostic, bioseparation or therapeutic applications. READ MORE

  4. 4. Selection and use of affinity proteins developed by combinatorial engineering

    University dissertation from Stockholm : Bioteknologi

    Author : Kristofer Sandström; KTH.; [2003]
    Keywords : phage display; combinatorial; selection; cd28; cllulosome; cellulose;

    Abstract : In affinity protein biotechnology the selective bindingbetween a chosen protein and an interacting biomolecule isutilized for a variety of applications including bioseparation,detection and therapy. Traditionally, affinity proteinsrecruited for such applications have been derived from naturalproteins or immunoglobulins generated via immunization routes. READ MORE

  5. 5. Rational and combinatorial protein engineering for vaccine delivery and drug targeting

    University dissertation from Stockholm : Bioteknologi

    Author : Maria Wikman; KTH.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; affibody; affinity chromatography; biotin; combinatorial; delivery; phage display; Biomedicin; MEDICINE Microbiology; immunology; infectious diseases Microbiology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi;

    Abstract : This thesis describes recombinant proteins that have been generated by rational and combinatorial protein engineering strategies for use in subunit vaccine delivery and tumor targeting. In a first series of studies, recombinant methods for incorporating immunogens into an adjuvant formulation, e.g. READ MORE