Search for dissertations about: "combined profiling"

Showing result 1 - 5 of 78 swedish dissertations containing the words combined profiling.

  2. 1. Development of Techniques for Characterization, Detection and Protein Profiling of Extracellular Vesicles

    Author : Sara Cavallaro; Jan Linnros; Apurba Dev; Hakho Lee; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular vesicles; streaming current; fluorescence microscopy; atomic force microscopy; scanning electron microscopy; protein profiling; size profiling; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Abstract : Nanosized extracellular vesicles (EVs, ∼30-2000 nm) have emerged as important mediators of intercellular communication, offering opportunities for both diagnostics and therapeutics. In particular, small EVs generated from the endolysosomal pathway (∼30-150 nm), referred to as exosomes, have attracted interest as a suitable biomarker for cancer diagnostics and treatment monitoring based on minimally invasive liquid biopsies. READ MORE

  4. 2. MOLECULAR PROFILING OF UROTHELIAL CARCINOMA

    Author : David Lindgren; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; Urology; nephrology; Urologi; nefrologi; Clinical genetics; Klinisk genetik; cytogenetics; Genetics; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; TP53; FGFR3; gene expression profiling; microarray; bladder cancer; urothelial carcinoma; Genetik;

    Abstract : The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. READ MORE

  5. 3. Combined profiling in aspen : a systems biology approach

    Author : Ogonna Obudulu; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : This thesis presents efficient systems biology modelling strategies for integrating complex multi-platform datasets in order to increase our understanding of stress biology, wood formation and secondary cell wall formation in Populus trees and connected responses to perturbations in organisms, particularly aspen. It is based on studies reported in four appended papers, designated Papers I-IV. READ MORE

  6. 4. Aspects of Gene Expression Profiling in Disease and Health

    Author : Julia Bergman; Fredrik Pontén; Lars Akslen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; biomarkers; differential diagnostics; immunohistochemistry; transcriptomics; protein profiling; adrenal gland.; Pathology; Patologi;

    Abstract : The aim of this thesis is to in various ways explore protein expression in human normal tissue and in cancer and to apply that knowledge in biomarker discovery.In Paper I the prognostic significance of RNA-binding motif protein 3 (RBM3) is explored in malignant melanoma. READ MORE

  7. 5. Tools and Methods for Analysis, Debugging, and Performance Improvement of Equation-Based Models

    Author : Martin Sjölund; Peter Fritzson; Christoph Kessler; Walid Mohamed Taha; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Simulation; modeling; debugging; profiling; optimization; parallelism; Modelica;

    Abstract : Equation-based object-oriented (EOO) modeling languages such as Modelica provide a convenient, declarative method for describing models of cyber-physical systems. Because of the ease of use of EOO languages, large and complex models can be built with limited effort. READ MORE