Search for dissertations about: "comet assay"

Showing result 21 - 25 of 27 swedish dissertations containing the words comet assay.

  2. 21. Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk

    Author : Charlotta Ryk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : polymorphisms; metabolism; DNA repair; p53; lung cancer; bladder cancer;

    Abstract : Individuals have different susceptibility towards environmental exposures that may cause or contribute to disease. This inter-individual variation is partly due to genetic polymorphisms in genes involved in DNA repair and metabolism, which have potential to modulate the function of the encoded proteins. READ MORE

  4. 22. Factors modifying cellular response to ionizing radiation

    Author : Lei Cheng; Andrzej Wojcik; Siamak Haghdoost; Lovisa Lundholm; Penelope A. Jeggo; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; DNA damage; gene expression; alpha particles; X-rays; mixed beams; gamma rays; hypothermia; dose rate.; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Many physical factors influence the biological effect of exposure to ionizing radiation, including radiation quality, dose rate and temperature. This thesis focuses on how these factors influence the outcome of exposure and the mechanisms behind the cellular response. READ MORE

  5. 23. Cellular responses to combined irradiation with alpha particles and X-rays

    Author : Alice Sollazzo; Andrzej Wojcik; Alexandros Georgakilas; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation; DNA damage; mutations; alpha particles; X-rays; mixed beam; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Mixed radiation fields, where different ionizing particles act together, are very important in radiobiology and in radiation protection. Mixed beams are not only the most common form of radiation exposure, but the prediction of their biological effect is also full of uncertainties. READ MORE

  6. 24. Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells

    Author : Mirjam Nordling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Polycyclic aromatic hydrocarbons; benzo[a]pyrene; colon cancer; genotoxicity; oxidative DNA damage.;

    Abstract : Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important risk factors associated with CRC. READ MORE

  7. 25. DNA lesions and carcinogenicity from the urban air pollutants 2- and 3-nitrobenzanthrone

    Author : Eszter Nagy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 3-nitrobenzanthrone; 2-nitrobenzanthrone; diesel exhaust; carcinogenicity; acute toxicity; DNA adducts; oxidative stress; intratracheal; ingestion;

    Abstract : In the early 1990's, Japanese doctors in urban areas discovered an increasing incidence of lung cancer among women, which was not attributed to a change in diet or smoking. This led to a growing investigation of urban air, and subsequently the discovery of 3-nitrobenzanthrone (3-NBA), a pollutant originating from diesel emissions. READ MORE