Search for dissertations about: "comparative genomic hybridization"

Showing result 11 - 15 of 55 swedish dissertations containing the words comparative genomic hybridization.

2. 11. Genomic and transcripto variation in blood stage Plasmodium falciparum

   Author : Bobo Mok; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Antigenic variation; comparative genomic hybridization CGH ; copy number polymorphism CNP ; microarray; P. falciparum; PfEMP1; subtelomeric regions; segmental duplication; switching; var;

   Abstract : Malaria research has entered a postgenomic era since October 2002, when the complete genomic sequence of Plasmodium falciparum strain 3D7 was published. A massive amount of information generated by the P. falciparum genome project has facilitated the development of many novel platforms for profiling different levels of biological aspects. READ MORE

4. 12. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome

   Author : Cecilia Nilsson; Marie-Louise Fjällskog; Leif Bergkvist; Thomas Hatschek; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male breast cancer; immunohistochemistry; prognostic; cyclins; gene expression; genomic profiling; Oncology; Onkologi; Oncology; Onkologi;

   Abstract : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. READ MORE

5. 13. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

   Author : Johan Staaf; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

   Abstract : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. READ MORE

6. 14. Genomic changes defining the progression of human colorectal and cervical tumors

   Author : Kerstin Heselmeyer; Karolinska Institutet; Karolinska Institutet; []
   Keywords : colorectal; cervical; anal neoplasias proliferation; DNA ploidy; p53 and p21WAF1 expression; HPV; CGH;

   Abstract : Defining changes during the carcinogenesis and progression of tumors is a major way to obtain a better understanding of the mechanisms of cancer development. We therefore investigated the carcinogenesis process in the colon-rectum and in the uterine cervix by different cell chemical, immunohistochemical and cytogenetic methods. READ MORE

7. 15. Application of Genomic and Expression Arrays for Identification of new Cancer Genes

   Author : Helena Nord; Teresita Díaz de Ståhl; Jan Dumanski; Susan Pfeifer; Blomquist Erik; Segersten Ulrika; David Gisselsson Nord; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Array-CGH; Expression array; Copy number variation; Glioblastoma; Medulloblastoma; Bladder carcinoma; Oncogenes; Tumor suppressor genes; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Medical genetics; Medicinsk genetik; Tumour biology; Tumörbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Abstract : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. READ MORE