Search for dissertations about: "complement activation"

Showing result 1 - 5 of 182 swedish dissertations containing the words complement activation.

  1. 1. Rules of engagement - Regulation of complement response in tissue

    University dissertation from Lund University, Faculty of Medicine

    Author : Anas Haider Abu-Humaidan; Lunds universitet.; Lund University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; Complement activation; Complement regulation; terminal complement complex; Staphylococcus auereus; atopic dermatitis; head and neck cancer; epidermal growth factor receptor; EGFR;

    Abstract : Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years. READ MORE

  2. 2. Complement Activation Triggered by Biomaterial Surfaces Mechanisms and Regulation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Andersson; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Biomaterials; Biocompatibility; Blood; Complement; Immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi; klinisk immunologi; Clinical Immunology;

    Abstract : Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. READ MORE

  3. 3. Complement in Disease - Extracellular Proteins as Complement Regulators

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Kaisa Happonen; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Abstract : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. READ MORE

  4. 4. The Role of IgM and Complement in Antibody Responses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christian Rutemark; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE

  5. 5. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin Activation and Binding to DNA

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Raber; Uppsala universitet.; [2007]
    Keywords : Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Abstract : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. READ MORE