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Showing result 1 - 5 of 213 swedish dissertations matching the above criteria.

  2. 1. Aspects of Complement Activation in Thrombocytopenic Disorders

    Author : Alexander Åkesson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thrombocytopenia; Complement activation; Complement dysregulation; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome; Platelet transfusion refractoriness;

    Abstract : The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. READ MORE

  4. 2. Rules of engagement - Regulation of complement response in tissue

    Author : Anas Haider Abu-Humaidan; Infektionsmedicin; []
    Keywords : Complement system; Complement activation; Complement regulation; terminal complement complex; Staphylococcus auereus; atopic dermatitis; head and neck cancer; epidermal growth factor receptor; EGFR;

    Abstract : Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years. READ MORE

  5. 3. Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation

    Author : Jonas Andersson; Bo Nilsson; Hans Elwing; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Biomaterials; Biocompatibility; Blood; Complement; Immunologi; Immunology; Immunologi; klinisk immunologi; Clinical Immunology;

    Abstract : Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. READ MORE

  6. 4. Complement in Disease - Extracellular Proteins as Complement Regulators

    Author : Kaisa Happonen; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Abstract : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. READ MORE

  7. 5. The Role of IgM and Complement in Antibody Responses

    Author : Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE