Search for dissertations about: "complement factor H"

Showing result 1 - 5 of 42 swedish dissertations containing the words complement factor H.

  2. 1. Interactions between platelets and complement with implications for the regulation at surfaces

    Author : Per H. Nilsson; Kristina Nilsson Ekdahl; John Lambris; Ian Nicholls; Berhane Ghebrehiwet; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complement system activation; regulation ; platelets activation; regulation ; biomaterials; biocompatibility; chondroitin sulfate-A; apyrase; C1q; C3; factor H; C4BP; ADP; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Disturbances of host integrity have the potential to evoke activation of innate immunologic and hemostatic protection mechanisms in blood. Irrespective of whether the activating stimulus is typically immunogenic or thrombotic, it will generally affect both the complement system and platelets to a certain degree. READ MORE

  4. 2. Studies of the role of complement factor H in hemolytic uremic syndrome

    Author : Fariba Vaziri Sani; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; Hemolytic uremic syndrome; complement system; factor H;

    Abstract : Factor H is the main fluid phase regulator of the alternative pathway of complement. Factor H acts as a co-factor for factor I-mediated C3b degradation, inhibits the formation of the C3bBb convertase and accelerates its decay. By discriminating between host and foreign cells, factor H inhibits complement-mediated injury to host cells. READ MORE

  5. 3. Crosstalk Between Activated Platelets and the Complement System

    Author : Osama A. Hamad; Bo Nilsson; Kristina Ekdahl-Nilsson; Lennart Truedsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; activated platelets; TRAP; chondroitin sulfate; C1q; factor H; C4BP; C3; Compstatin; complement; platelet-leukocyte complexes; platelet microparticles; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Abstract : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. READ MORE

  6. 4. Platelet activation and tissue factor release in hemolytic uremic syndrome

    Author : Anne-lie Ståhl; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hemolytic uremic syndrome; platelets; tissue factor; LPS; Shiga toxin; complement system; factor H; clusterin;

    Abstract : Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. There are two subtypes: typical HUS associated with enterohemorrhagic E. coli (EHEC) and atypical HUS associated with uninhibited activation of the alternative pathway of complement. READ MORE

  7. 5. The role of the thromboinflammatory response under hemolytic conditions : pathophysiological mechanisms and therapeutic inhibition

    Author : Alexandra Gerogianni; Per H. Nilsson; Camilla Mohlin; Tom Eirik Mollnes; Kristina Nilsson Ekdahl; Mihály Józsi; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hemolysis; heme; thromboinflammation; biomaterials; complement inhibition; LVAD; IONPs; Biomedical Sciences; Biomedicinsk vetenskap; Immunologi; Immunology;

    Abstract : In blood circulation, the complement and the coagulation cascades, together with platelets and endothelial cells form a complex network of crosstalk. When dysregulated, these interactions can lead to inflammation in combination with thrombosis (thromboinflammation) and the manifestation of pathophysiological complications. READ MORE