Search for dissertations about: "composite score"

Showing result 1 - 5 of 36 swedish dissertations containing the words composite score.

  2. 1. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

    Author : Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE

  4. 2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Author : Lars Ängquist; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

  5. 3. Psychometric studies of the Swedish version of the Adolescent Drug Abuse Diagnosis (ADAD) instrument

    Author : Josefine Börjesson; Helene Ybrandt; Bengt-Åke Armelius; Anders Tengström; Umeå universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; ADAD; validity; reliability; assessment; psychometric; severity index; composite score; normal; antisocial adolescents; psychological health;

    Abstract : This thesis describes studies into the psychometric properties of a Swedish language version of the Adolescent Drug Abuse Diagnosis (ADAD) instrument. The psychometric properties of this instrument have been examined in two previous studies: an American study was conducted by the developers of the interview, Friedman and Utada (1989), and a Swiss study was undertaken by Bolognini et al. READ MORE

  6. 4. Enhancing Composite Cassava Bread Quality - Effect of cassava pre-treatment and baking improvers

    Author : Maria Eduardo; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; baking improvers; bread quality; cassava flour; pre-treatment; composite bread; sensory evaluation;

    Abstract : Due to unfavourable climatic conditions, the production of wheat in Mozambique is not sufficient to satisfy national food industrial needs and substantial quantities must be imported at high cost. Bread is currently produced basically using wheat flour. READ MORE

  7. 5. Some Investigations into the Class of Exponential Power Distributions

    Author : Lukas Arnroth; M. Rauf Ahmad; Patrik Andersson; Matúš Maciak; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Exponential power distribution; Skewed exponential power distribution; linear mixed models; score test; Lp-quantiles; quantile regression; posterior convergence rate; Statistics; Statistik;

    Abstract : In this thesis, methods are developed relating to the exponential power class of distributions.Paper I considers Bayesian linear mixed models where the usual normality assumption is replaced by the multivariate exponential power distribution. Particular focus lies on Bayesian testing of the fixed effects. READ MORE