Search for dissertations about: "computational proteomics"

Showing result 6 - 10 of 24 swedish dissertations containing the words computational proteomics.

  2. 6. Proteomic profiling of osteoarthritis. A computational approach to biomarker discovery

    Author : Martin Rydén; Lund Ortopedi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Biology; Bioinformatics for Proteomics;

    Abstract : Understanding the molecular mechanisms of osteoarthritis (OA) is critical for early diagnosis and effective treatment. OA is a leading cause of disability and poses an increasing burden on healthcare systems, particularly with an aging global population. READ MORE

  4. 7. Computational analyses of biological sequences -applications to antibody-based proteomics and gene family characterization

    Author : Mats Lindskog; Mathias Uhlén; Fredrik Sterky; Andersson Björn; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antigen; antibodies; antibody-based proteomics; biocomputing; bioinformatics; Bioinformatics; Bioinformatik;

    Abstract : Following the completion of the human genome sequence, post-genomic efforts have shifted the focus towards the analysis of the encoded proteome. Several different systematic proteomics approaches have emerged, for instance, antibody-based proteomics initiatives, where antibodies are used to functionally explore the human proteome. READ MORE

  5. 8. Computing abundance constraints in Saccharomyces cerevisiae’s metabolism

    Author : Benjamín José Sánchez; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome-scale modeling; lipidomics; proteomics; flux balance analysis;

    Abstract : The unicellular eukaryotic organism Saccharomyces cerevisiae (budding yeast) is routinely used for production of high-value chemical compounds in the biotechnology industry. To improve production yields, it is fundamental to understand cellular metabolism, i.e. all biochemical reactions that occur inside the cell. READ MORE

  6. 9. On computational methods for spatial mapping of the human proteome

    Author : Casper F. Winsnes; Emma Lundberg; Ida-Maria Sintorn; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spatial proteomics; Human Protein Atlas; Micronuclei; Citizen science; Biotechnology; Bioteknologi;

    Abstract : Proteins are complex molecules that are involved in almost every task in the body. In general, the role a protein fulfills is highly dependent on where in the cell it is located, its subcellular localization. READ MORE

  7. 10. Parameterized algorithms for hitting set variants applied to protein identification in shotgun proteomics

    Author : Leonid Molokov; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Fixed Parameter Tractable; Shotgun proteomics; Hitting Set; Parameterized complexity; Hypergraph; Set Cover;

    Abstract : This work is dedicated to problem of protein identification in bottom-up proteomics, and in particular, in shotgun proteomics. It is aimed on providing a new way of interpretation of peak lists. READ MORE