Search for dissertations about: "computational systems biology"

Showing result 1 - 5 of 149 swedish dissertations containing the words computational systems biology.

  2. 1. Computational modelling in systems biology: from rewriting cell fates to detecting tumours

    Author : Emil Andersson; Centrum för miljö- och klimatvetenskap (CEC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Beräkningsmodeller; Systembiologi; Genreguleringsnätverk; Cellomprogrammering; Energilandskap; iPSC; Agentbaserad modellering; T-cellsutveckling; Maskininlärning; Tumördiagnostik; Computational modelling; Systems biology; Gene regulatory network; Cell reprogramming; Energy landscape; iPSC; Agent-based modelling; Multi-scale modelling; T-cell development; Machine learning; Tumour diagnostics;

    Abstract : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. READ MORE

  4. 2. Computational Ecotoxicology

    Author : Sergio Manzetti; David Van der Spoel; Janez Mavri; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pollutants; simulation; molecular; dynamic; quantum; chemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Human society has progressed by polluting ecosystems since at least the early industrial revolution. Large amounts of harmful chemical compounds have been dispersed in soils, seas, ground waters and wildlife habitats by industrial and anthropomorphic activities over the last two centuries, leading to a persistent toxicological load on the environment. READ MORE

  5. 3. microRNAs: from biogenesis to organismal tracing

    Author : Wenjing Kang; Marc Friedländer; Jens Lagergren; Ulf Ørom; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNA; microRNA biogenesis; taxonomical identification; high throughput sequencing; xenomiRs; RNA structure; high throughput screening; molekylär biovetenskap; Molecular Bioscience;

    Abstract : MicroRNAs (miRNAs) are short noncoding RNAs of around 22 nucleotides in length, which help to shape the expression of most mRNAs. Perturbation of miRNA expression has revealed a variety of defects in development, cell specification, physiology and behavior. READ MORE

  6. 4. Multiscale Modeling in Systems Biology : Methods and Perspectives

    Author : Adrien Coulier; Andreas Hellander; Mark Chaplain; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; computational systems biology; high performance computing; Bayesian inference; stochastic simulation; cell mechanics; Scientific Computing; Beräkningsvetenskap;

    Abstract : In the last decades, mathematical and computational models have become ubiquitous to the field of systems biology. Specifically, the multiscale nature of biological processes makes the design and simulation of such models challenging. READ MORE

  7. 5. Inference of Hierarchical Structure in Complex Systems

    Author : Olof Görnerup; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Substitution groups; Modularity; Hierarchical dynamics; RNA world; Genetic code; Aggregation; Primordial evolution; Molecular evolution; Model reduction; Self-organization; Lumping; Emergence; Coarse graining;

    Abstract : Hierarchical organization is a central property of complex systems. It is even argued that a system is required to be hierarchical in order to evolve complexity within reasonable time. A hierarchy of a system is defined as the set of self-contained levels at which the system operates and can be described on. READ MORE