Search for dissertations about: "concentration-effect relationship."

Showing result 1 - 5 of 9 swedish dissertations containing the words concentration-effect relationship..

2. 1. Pharmacokinetics of the enantiomers of thalidomide

   Author : Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. READ MORE

4. 2. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling

   Author : Marie Gårdmark; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Abstract : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. READ MORE

5. 3. Quinine as a model for the study of cochlear hearing loss in humans

   Author : Erik Berninger; Karolinska Institutet; Karolinska Institutet; []
   Keywords : cochlear function; hearing loss; inner ear; otoacoustic emissions; quinine; pharmacokinetics; pharmacodynamics;

   Abstract : Quinine has been used for centuries and is still recommended for the treatment of severe falciparum malaria and non-severe chloroquine-resistant malaria. Among its side effects is the concentration-dependent and reversible cochlear hearing loss. READ MORE

6. 4. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

   Author : Sofia Friberg Hietala; Göteborgs universitet; []
   Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

   Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

7. 5. Pharmacokinetics - Effect Relations of Glibenclamide and its Metabolites in Humans

   Author : Tony S Rydberg; Institutionen för hälsovetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal insufficiency.; insulin; glucose; non-insulin dependent; diabetes mellitus; pharmacodynamic modelling; pharmacodynamics; pharmaco-kinetics; HPLC method; Glibenclamide; sulphonylurea; metabolites; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : Glibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE