Search for dissertations about: "conditional knock-out"

Showing result 1 - 5 of 7 swedish dissertations containing the words conditional knock-out.

  2. 1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Author : Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Abstract : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). READ MORE

  4. 2. Aspects of T cell development contributing to autoimmunity

    Author : Maria Carlsén; Diabetes - immunovirologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Abstract : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. READ MORE

  5. 3. Effects of PDGF-B gene inactivation in endothelial cell

    Author : Mattias Bjarnegård; Göteborgs universitet; []
    Keywords : gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Abstract : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. READ MORE

  6. 4. Transcriptional regulation of ribosome biogenesis in skeletal muscle growth

    Author : Chang Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Resistance exercise induces skeletal muscle hypertrophy via repeated exercise bouts. The increased muscle protein synthesis together with altered muscle protein degradation contribute to the adaptation of muscle mass. The number of ribosomes dictates the protein synthetic capacity of muscle. READ MORE

  7. 5. Role of PAK4 in pancreas development and breast cancer

    Author : Miao Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality and mice with conditional PAK4 gene depletion in the heart and in the central nervous system displayed serious organ defects. READ MORE