Search for dissertations about: "conditioning loci"

Found 3 swedish dissertations containing the words conditioning loci.

  2. 1. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Author : Lars Ängquist; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

  4. 2. Species Delimitation and Phylogenetic Relationships. A study of Silene sections Atocion and Cryptoneurae

    Author : Zeynep Aydin; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Caryophyllaceae; Silene; Section Atocion; S. ertekinii; S. cryptoneura; S. aegyptiaca; SystematicsPhylogenetics; Species delimitation; Multispecies coalescent; Marginal likelihood; Species tree; DISSECT.;

    Abstract : Abstract The existence of conflicting genealogies of different genes through the evolution of species complicates the inference of phylogenetic relationships. The Multispecies Coalescent (MSC) model provides a theoretical background that account for the stochasticity in the genealogical process, thus providing systematists with a potentially objective way of testing alternative hypotheses of putative species. READ MORE

  5. 3. Mapping genetic diseases in northern Sweden

    Author : Elisabet Einarsdottir; Dan Holmberg; Gösta Holmgren; Ulf Gyllensten; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; isolated populations; linkage disequilibrium; linkage analysis; genome-wide scan; hereditary sensory and autonomic neuropathy; type 1 diabetes mellitus; type 2 diabetes mellitus; autoimmune thyroid disease; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

    Abstract : The population of northern Sweden has previously been shown to be well suited for the mapping of monogenic diseases. In this thesis we have tested the hypothesis that this population could also be used for efficient identification of risk genes for common diseases. READ MORE