Search for dissertations about: "conformational analysis"

Showing result 6 - 10 of 145 swedish dissertations containing the words conformational analysis.

  2. 6. Light-Triggered Conformational Switches for Modulation of Molecular Recognition : Applications for Peptidomimetics and Supramolecular Systems

    Author : Magnus Blom; Adolf Gogoll; Morten Grötli; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bisporphyrin tweezers; peptidomimetics; host-guest systems; conformational analysis; supramolecular chemistry; photochemistry; Organisk kemi; Organic Chemistry; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Abstract : The main focus of this thesis is on photochemical modulation of molecular recognition in various host-guest systems. This involves the design, synthesis and integration of light-triggered conformational switches into peptidomimetic guests and molecular tweezer hosts. READ MORE

  4. 7. Dopaminergic 2-aminotetralins : synthesis, conformational analysis, and structure-activity relationships

    Author : Anette M. Johansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 8. 5-HT1A-receptor agonists : synthesis, conformational analysis and structure-activity relationships

    Author : Charlotta Mellin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 9. Computational Study of Calmodulin’s Ca2+-dependent Conformational Ensembles

    Author : Annie M. Westerlund; Erik Lindahl; Lucie Delemotte; Björn Wallner; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; Calmodulin; Free energy estimation; Gaussian mixture models; Spectral clustering; conformational selection; Biological Physics; Biologisk fysik;

    Abstract : Ca2+ and calmodulin play important roles in many physiologically crucial pathways. The conformational landscape of calmodulin is intriguing. Conformational changes allow for binding target-proteins, while binding Ca2+ yields population shifts within the landscape. Thus, target-proteins become Ca2+-sensitive upon calmodulin binding. READ MORE

  7. 10. Shape Matters : Characterization of Weak Interactions and Macrocycles by Conformational Analysis

    Author : Stefan Peintner; Máté Erdélyi; Oliver Zerbe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : When studying conformational ensembles, it is most challenging to identify and characterize rapidly interconverting individual conformers. A precise description of the structural dynamics, however, rewards viable knowledge on conformation stabilizing forces as well as on the impact of external influences on the conformer composition. READ MORE